Article: The Importance of Calcium, Potassium, and Acid-Base Homeostasis in Bone Health and Osteoporosis Prevention1,2

The acid ash hypothesis proposed by Wachman and Bernstein (1) in 1968 put forth the paradigm that the net acid produced from the Westernized diet could contribute to the development of osteoporosis. Algorithms designed specifically to quantify the relative acidity of the diet have been developed. These equations are empirically derived relationships between nutrient analysis from food tables and the quantity of acid excreted in the urine (2,3) and estimate net endogenous acid production (4). The underlying premise of these diet-based algorithms is that dietary intake is the modulating factor that protects bone against excess metabolic acid production. In healthy individuals, the buffering ...

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