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Article: The presence of bla^sub IMP^ genes on plasmids DNA isolated from multidrug - resistant Pseudomonas aeruginosa strains at University Hospital in Bialystok (Poland) - first report

Article from:
Folia Histochemica et Cytobiologica
Article date:
October 1, 2007
Author:
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Abstract: Resistance to carbapenems is emerging, and it is a great problem to therapeutics. Seven multidrug-resistant (MDR) of Pseudomonas aeruginosa strains were isolated from urine and bronchial specimens. All isolates showed resistance to imipenem and meropenem (MIC; =16 mg/L). The resistance to carbapenems in two of seven strains was associated with the production of a metallo-ß-lactamases. Plasmids DNA probes were used to investigate the presence of genes coding for IMP-type enzymes. PCR experiments revealed that blaIMP genes were present in two isolates of Pseudomonas aeruginosa (MIC >32 µg/mL for both carbapenems).

Keywords: Pseudomonas aeruginosa - Metallo-ß-lactamases - ...

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