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Article: Raloxifene, soy phytoestrogens and endothelial function in postmenopausal women
- Article from:
- Climacteric
- Article date:
- December 1, 2007
- Author:
CopyrightCopyright Taylor & Francis Ltd. Dec 2007. Provided by ProQuest LLC. (Hide copyright information)
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Key words: ENDOTHELIAL FUNCTION, VASODILATION, BRACHIAL ARTERY, RALOXIFENE, SOY, PHYTOESTROGENS, POSTMENOPAUSAL WOMEN
ABSTRACT
Objective To compare the effects of raloxifene and soy phytoestrogens on endothelial function in healthy, postmenopausal women.
Design Randomized, double-blind, placebo-controlled, cross-over trial. Subjects (n = 22; mean age 58.5 years) underwent endothelial function testing at baseline and following 6 weeks of daily raloxifene 60 mg, soy phytoestrogens 55 mg, and placebo in random sequence with intervening 6-week wash-out periods. Endothelial function was assessed as flow-mediated vasodilatation (FMD) of the brachial artery using high-resolution ultrasound; ...