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Article: Lymphocyte propionyl-CoA carboxylase is an early and sensitive indicator of biotin deficiency in rats, but urinary excretion of 3-hydroxypropionic acid is not
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2002. Provided by ProQuest LLC. (Hide copyright information)
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Lymphocyte Propionyl-CoA Carboxylase Is an Early and Sensitive Indicator of Biotin Deficiency in Rats, but Urinary Excretion of 3-Hydroxypropionic Acid Is Not1
ABSTRACT Recent clinical studies have provided evidence that marginal biotin deficiency is more common than previously thought. The validity of that conclusion rests on two indicators of biotin status that depend on renal function. Our goal was to develop and assess the usefulness of two additional indicators in detecting marginal biotin status in a rat model, i.e., 1) activity of the biotin-dependent enzyme propionyl-CoA carboxylase in lymphocytes; and 2) urinary excretion of 3-hydroxypropionic acid, an organic acid that reflects ...