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Article: Bacterial infection affects protein synthesis in primary lymphoid tissues and circulating lymphocytes of rats
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2002. Provided by ProQuest LLC. (Hide copyright information)
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Bacterial Infection Affects Protein Synthesis in Primary Lymphoid Tissues and Circulating Lymphocytes of Rats1
ABSTRACT Bacterial infection alters whole-body protein homeostasis. Although immune cells are of prime importance for host defense, the effect of sepsis on their protein synthesis rates is poorly documented. We analyzed protein synthesis rates in rat primary lymphoid tissues and circulating lymphocytes after infection. Male Sprague-Dawley rats were studied 1, 2, 6 or 10 d after an intravenous injection of live Escherichia coli. Control healthy rats consumed food ad libitum (d 0) or were pair-fed to infected rats. Protein synthesis was quantified using a flooding dose of ...