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Article: Dietary genistein affects brain protein synthesis rates in ovariectomized female rats
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2002. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT The purpose of this study was to determine whether genistein affects the rate of brain protein synthesis in ovariectomized female rats. Experiments were conducted on three groups of 12-wk-old female rats: those in group 1 were ovariectomized to reduce the level of plasma sex hormone; those in group 2 were ovariectomized and fed diets containing 0.01 % genistein; and those in group 3 were sham-operated controls. The fractional rates of protein synthesis in the brain of ovariectomized rats fed genistein were significantly greater than those in ovariectomized rats without genistein treatment. In the cerebral cortex and cerebellum, the RNA activity [g protein synthesized/(g RNA*d)] ...