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Article: Indapamide-Induced Prevention of Myocardial Fibrosis in Spontaneous Hypertension Rats Is Not Nitric Oxide-Related

Article from:
Physiological Research
Article date:
November 1, 2007
Author:
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Summary

We studied the effect of thiazide-like diuretic - indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) and assessed the involvement of nitric oxide in this process. Six-week-old male SHR were treated with indapamide (1 mg/kg/day) for six weeks. Age-matched SHR were used as hypertensive and Wistar-Kyoto rats (WKY) as normotensive control. Systolic blood pressure was measured by tail-cuff plethysmography. Nitric oxide synthase (NOS) activity, protein expressions of endothelial (eNOS) and inducible NOS (iNOS), myocardial fibrosis and collagen type I and III were determined in the left ventricle. Indapamide treatment partially prevented ...

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