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Article: Silymarin, a Flavonoid from Milk Thistle (Silybum marianum L.), Inhibits UV-induced Oxidative Stress Through Targeting Infiltrating CD11b^sup +^ Cells in Mouse Skin[dagger]
- Article from:
- Photochemistry and Photobiology
- Article date:
- March 1, 2008
- Author:
CopyrightCopyright American Society for Photobiology Mar/Apr 2008. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Phytochemicals have shown promise in inhibiting UV-induced oxidative stress, and therefore are considered as potent inhibitors of UV-induced oxidative stress-mediated skin diseases. We have shown previously that topical treatment of silymarin, a flavonoid from milk thistle (Silybum marianum), inhibits UV-induced oxidative stress in mouse skin. However, the cellular targets responsible for the inhibition of UV-induced oxidative stress by silymarin are not clearly defined. To address this issue, C3H/HeN mice were UV irradiated (90 mJ cm^sup -2^) with or without topical treatment with silymarin (1 mg cm^sup -2^ skin area). Mice were killed 48 h later and skin samples collected. Flow ...