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Article: Association of body mass index and Trp64Arg polymorphism of the [beta]^sub 3^-adrenoreceptor gene and leptin level in Tehran Lipid and Glucose Study
- Article from:
- British Journal of Biomedical Science
- Article date:
- July 1, 2007
- Author:
CopyrightCopyright Step Communications Ltd. 2007. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
In this study the association between β^sub 3^-adrenoceptor gene polymorphism and serum concentration of leptin with body mass index (BMI) is investigated. Using subjects in the Tehran Lipid and Glucose Study, genotyping of the Trp64Arg polymorphism of the β^sub 3^-adrenoreceptor gene was performed using a restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique was used and the association with obesity was investigated. At total of 197 men and 204 women were divided into four groups (BMI<20, 20≤BMI<25, 25≤BMI<30, BMI≤30) and 97, 98, 104 and 102 subjects, respectively, were placed randomly in the four groups. ...