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Article: Clonidine as an Adjuvant to Intrathecal Local Anesthetics for Surgery: Systematic Review of Randomized Trials

Article from:
Regional Anesthesia and Pain Medicine
Article date:
March 1, 2008
Author:
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Background and Objectives: Clonidine is added to intrathecal local anesthetics to improve intraoperative analgesia and to increase the duration of sensory and motor block. The aim of this systematic review is to quantify beneficial and harmful effects of Clonidine when used as an adjuvant to intrathecal local anesthetics for surgery.

Methods: We included data from 22 randomized trials (1,445 patients) testing a large variety of doses of Clonidine, added to intrathecal bupivacaine, mepivacaine, prilocaine, or tetracaine.

Results: Clonidine 15 to 150 µg prolonged in a linear, dose-dependent manner, the time to 2 segment regression (range of means, 14 to 75 minutes) and the time to regression ...

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