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How Polymers Translocate Through Pores: Memory is Important
- Article from:
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Biophysical Journal
- Article date:
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March 1, 2008
- Author:
- Kolomeisky, Anatoly B
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Copyright informationCopyright Biophysical Society Mar 1, 2008. Provided by ProQuest LLC. (Hide copyright information)
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Many biological processes, such as DNA and RNA transport across nuclear pores, injections of viral DNA, gene swapping, and protein transport across cellular membranes, involve the motion of polymer molecules across narrow channels (1). Translocation through nanopores is also one of the most important and powerful methods for analyzing properties of single biopolymer molecules and for investigating different biophysical phenomena (2,3). The polymer translocation is generally viewed as an effective one-dimensionally activated process that involves overcoming the entropie barriers. These barriers appear due to the decrease in the number of available polymer configurations in the translocating ...