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The Structure of Isolated Cardiac Myosin Thick Filaments from Cardiac Myosin Binding Protein-C Knockout Mice
- Article from:
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Biophysical Journal
- Article date:
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March 1, 2008
- Author:
- Kensler, Robert W; Harris, Samantha P
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Copyright informationCopyright Biophysical Society Mar 1, 2008. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Mutations in the thick filament associated protein cardiac myosin binding protein-C (cMyBP-C) are a major cause of familial hypertrophic cardiomyopathy. Although cMyBP-C is thought to play both a structural and a regulatory role in the contraction of cardiac muscle, detailed information about the role of this protein in stability of the thick filament and maintenance of the ordered helical arrangement of the myosin cross-bridges is limited. To address these questions, the structure of myosin thick filaments isolated from the hearts of wild-type mice containing cMyBP-C (cMyBP-C^sup +/+^) were compared to those of cMyBP-C knockout mice lacking this protein (cMyBp-C^sup -/-^). The ...