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Premature ovarian failure due to cyclophosphamide: A report of four cases in dermatology practice

Introduction

Immunological mechanisms are involved in the pathogenesis of many skin diseases. In the absence of any identifiable cause, suppressing the clinical manifestations by using immunosuppressants remains the only treatment option. A variety of immunosuppressants are used in dermatology. Cyclophosphamide is used as an immunosuppressant in the management of pemphigus vulgaris, bullous pemphigoid, connective tissue disorders like systemic lupus erythematous (SLE), scleroderma, dermatomyositis, neutrophilic dermatoses like pyoderma gangrenosum, Behηet's disease, various types of vasculitis like Wegner's granulomatosis, polyarteritis nodosa, leukocytoclastic vasculitis, ...

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