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Omalizumab in severe chronic urticaria

Sir,

Urticaria patients are usually treated with oral antihistamines and 50% of them respond well to this treatment. However, the other 50% do not respond to antihistamines and need a more aggressive approach. Approximately 40-50% of patients with no apparent cause for their urticaria are believed to have an associated autoimmune profile that may play a pathogenetic role. We describe here a patient who responded to omalizumab after failure to respond to cyclosporine.

A forty-five-year old female presented with severe chronic urticaria prevalent for the last ten years and which did not respond to antihistamines and steroids. About five years ago, the patient was diagnosed to have sarcoidosis ...

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