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Hypothesis: The potential utility of topical eflornithine against cutaneous leishmaniasis
- Article from:
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Indian Journal of Dermatology, Venereology and Leprology
- Article date:
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March 1, 2008
- Author:
- Namazi, M
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Copyright informationCopyright Medknow Publications Mar/Apr 2008. Provided by ProQuest LLC. (Hide copyright information)
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Sir,
The trypanothione biosynthetic pathway is common to the trypanosomatid family of protozoa, which includes Leishmania and Trypanosoma, and is absent in the host systems. This pathway constitutes an important target for chemotherapy against leishmaniasis. The trypanothione pathway combines two metabolic pathways: the glutathione and the polyamine biosynthetic pathways, to produce trypanothione, a glutathione-spermidine conjugate. [1]
The levels of trypanothione are increased in the Leishmania parasite selected for resistance to the heavy metal, arsenic. The levels of putrescine and spermidine were increased in resistant mutants. This increase is mediated by overexpression of ornithine ...
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POLYAMINES AND THE INTESTINAL TRACT
Critical Reviews in Clinical Laboratory Sciences;
July 1, 2007 ;
Seiler, Nikolaus; Raul, Francis;
787 words
......the selective inactivation of ornithine decarboxylase appears to be a promising chemopreventive...Presumably, it relies on the fact that ornithine decarboxylase is a critical regulator of the...OAZ, ornithine antizyme; ODC, ornithine decarboxylase; p21, p27, p53, cell-cycle ...
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Maternal dietary protein deficiency decreases nitric oxide synthase and...
The Journal of Nutrition;
December 1, 1998 ;
Wu, Guoyao; Pond, Wilson G; Flynn, Sean P; Ott, Troy L; Bazer, Fuller W;
787 words
......Decreases Nitric Oxide Synthase and Ornithine Decarboxylase Activities in Placenta and Endometrium...activities of NO synthase (NOS) and ornithine decarboxylase (ODC) (the first and key regulatory...malnutrition * nitric oxide synthase ornithine decarboxylase . fetus . pig Evvard et ...
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Protective Effect of the Isoflavonoid Equol Against Hairless Mouse Skin...
Photochemistry and Photobiology;
January 1, 2005 ;
Widyarini, Sitarina; Husband, Alan J; Reeve, Vivienne E;
787 words
......tumor promotion biomarker enzyme, ornithine decarboxylase, in the skin, suggesting the anticarcinogenic...minimal edematous dose; ODC, ornithine decarboxylase; SCC, squamous cell carcinoma...also the activation of the enzyme ornithine decarboxylase (ODC) and the synthesis of ...
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Sabinsa files new patent. (Business in Brief).(Eflornithine...
Chemical Market Reporter;
October 21, 2002 ;
48 words
......filed a new process patent at the US Patent and Trademark Office on the manufacture of Eflornithine hydrochloride, an ornithine decarboxylase inhibitor. Eflornithine is a fluorinated amino acid having applications in the treatment of the deadly African Sleeping...
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Cellular damage: mobile telephones and cancer.
The Economist (US);
February 6, 1993 ;
730 words
......per second, increased the activity of an enzyme called ornithine decarboxylase in cultured cells. The products of ornithine decarboxylation...may be one of the factors associated with increased ornithine decarboxylase activity. Even if these results are confirmed, users...
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Wake-up call. (sleeping sickness)
The Economist (US);
December 22, 1990 ;
751 words
......works in a different way, by blocking the action of ornithine decarboxylase, an enzyme that makes vital cellular chemicals called...try to prevent cancer of the colon. Tests showed that ornithine decarboxylase, the enzyme blocked by DFMO, is found in abnormally...
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Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as...
The Journal of Nuclear Medicine;
January 1, 2008 ;
Hsieh, Chia-Hung; Chen, Fu-Du; Wang, Hsin-Ell; Hwang, Jeng-Jong; Chang, Chi-Wei; Lee, Yi-Jang; Gelovani, Juri G; Liu, Ren-Shyan;
787 words
......the degradation domain of mouse ornithine decarboxylase to the C-terminal end. The protein...thymidine kinase (HSV1-TK); mouse ornithine decarboxylase (MODC); doxycycline (Dox); nuclear...in mammalian cells (5). Mouse ornithine decarboxylase (MODC) is the key enzyme in the...
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Old drug combo prevents colorectal adenomas.(Gastroenterology)(Clinical...
Internal Medicine News;
May 15, 2008 ;
Bates, Betsy;
746 words
......difluoromethylornithine (DFMO), a synthetic inhibitor of ornithine decarboxylase, and sulindac (Clinoril), an NSAID, in 375 patients...Tucson, to fight the development of cancer by targeting ornithine decarboxylase, a key polyamine pathway that acts as an instigator...
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Cranberry and Its Phytochemicals: A Review of In Vitro Anticancer...
The Journal of Nutrition;
January 1, 2007 ;
Neto, Catherine C;
787 words
......include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases...bilberry, and other fruits were observed to inhibit ornithine decarboxylase (ODC) expression and induce the xenobiotic detoxification...
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Old drug combo prevents colorectal adenomas.(Digestive Disorders)
Family Practice News;
May 15, 2008 ;
Bates, Betsy;
787 words
......difluoromethylornithine (DFMO), a synthetic inhibitor of ornithine decarboxylase, and sulindac (Clinoril), a nonsteroidal, anti-inflammatory...Tucson, to fight the development of cancer by targeting ornithine decarboxylase, a key polyamine pathway that acts as an instigator...
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Polyamine metabolism is altered in unpollinated parthenocarpic pat-2...
Plant Physiology;
January 1, 2003 ;
Fos, Mariano; Proano, Karina; Alabadi, David; Nuez, Fernando; Et al;
787 words
......Carbonell J (1996) Arginase, arginine decarboxylase, ornithine decarboxylase, and polyamines in tomato ovaries: changes in unpollinated...1237-1244 Alabadi D, Carbonell J (1998) Expression of ornithine decarboxylase is transiently increased by pollination, 2,4-dichlorophenoxyaacetic...
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Effect of salinity on arginine biosynthesis in leaves of Phaseolus...
Crop Science;
March 1, 1997 ;
Lazcano-Ferrat, Ignacio Lovatt, Carol J.;
787 words
......decarboxylase pathway. Arginine decarboxylase activity, but not ornithine decarboxylase, increased during water-deficit stress induced by various...difluoromethyl-omithine, an analogous specific inhibitor of ornithine decarboxylase, did not inhibit the stress-induced accumulation of...
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Whole-protein-based enteral formula stimulates intestinal ornithine...
JPEN, Journal of Parenteral and Enteral Nutrition;
July 1, 1999 ;
Yang, Hua; Wiren, Mikael; Larsson, Jorgen; Permert, Johan;
787 words
......effects of enteral formula vs specific amino acids on ornithine decarboxylase (ODC) activity and adenine nucleotide metabolism in...starvation or trauma is initiated by an early peak of ornithine decarboxylase (ODC) activity.l2 ODC is the enzyme that starts the...
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Early weaning induces jejunal ornithine decarboxylase and cell...
The Journal of Nutrition;
October 1, 1998 ;
Lin, Chuan-Hao; Correia, Leena; Tolia, Ketan; Gesell, Mark S; Et al;
787 words
...Early Weaning Induces Jejunal Ornithine Decarboxylase and Cell Proliferation in Neonatal...Gordon D. Luk* ABSTRACT Increased ornithine decarboxylase (ODC) activity is associated with...1998. KEY WORDS: rats weaning ornithine decarboxylase intestinal growth * cell proliferation...
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Regulation by polyamines of ornithine decarboxylase activity and cell...
Plant Physiology;
April 1, 2002 ;
Theiss, Christine; bohley, Peter; Voigt, Jurgen;
787 words
...Regulation by Polyamines of Ornithine Decarboxylase Activity and Cell Division in the Unicellular...and spermine) is dependent on the activity of ornithine decarboxylase (ODC, EC 4.1.1.17) catalyzing the formation of...
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