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Article: Biotin Deficiency Affects the Proliferation of Human Embryonic Palatal Mesenchymal Cells in Culture1,2
- Article from:
- The Journal of Nutrition
- Article date:
- April 1, 2008
- Author:
CopyrightCopyright American Institute of Nutrition Apr 2008. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
It has recently been demonstrated that pregnancy in women may cause mild biotin deficiency without any clinical signs. However, the teratogenicity of biotin deficiency in humans has not been well investigated. On the other hand, our previous studies have shown that maternal biotin deficiency induces many kinds of malformations, such as cleft palate, micrognathia, and micromelia, in all animal fetuses. However the mechanism for cleft palate induction under biotin-deficient conditions is unknown. Therefore, to investigate the possible mechanisms for cleft palate induction in embryos, we investigated the effects of biotin deficiency on human embryonic palatal mesenchymal (HEPM) cells ...