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Interactions Between Stressful Environment and Gene Deletions Alleviate the Expected Average Loss of Fitness in Yeast
- Article from:
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Genetics
- Article date:
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April 1, 2008
- Author:
- Jasnos, Lukasz; Tomala, Katarzyna; Paczesniak, Dorota; Korona, Ryszard
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Copyright informationCopyright Genetics Society of America Apr 2008. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
The conjecture that the deleterious effects of mutations are amplified by stress or interaction with one another remains unsatisfactorily tested. It is now possible to reapproach this problem systematically by using genomic collections of mutants and applying stress-inducing conditions with a well-recognized impact on metabolism. We measured the maximum growth rate of single- and double-gene deletion strains of yeast in several stress-inducing treatments, including poor nutrients, elevated temperature, high salinity, and the addition of caffeine. The negative impact of deletions on the maximum growth rate was relatively smaller in stressful than in favorable conditions. In both ...
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183 words
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250 words
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