Article: Diagnostic Accuracy of ^sup 11^C-Methionine PET for Differentiation of Recurrent Brain Tumors from Radiation Necrosis After Radiotherapy

We evaluated the diagnostic accuracy of PET with L-methyl-^sup 11^C-methionine (^sup 11^C-MET) for the differentiation of recurrent brain tumors from radiation necrosis. Methods: Seventy-seven patients who had been previously treated with radiotherapy after primary treatment for metastatic brain tumor (n = 51) or glioma (n = 26) were studied to clarify the diagnostic performance of ^sup 11^C-MET PET in differentiating between recurrent brain tumors and radiation necrosis. A total of 88 PET scans with ^sup 11^C-MET were obtained; sometimes more than one scan was obtained when there was an indication of recurrent brain tumor or radiation necrosis. A definitive diagnosis was made on the basis ...

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