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Article: ^sup 203^Pb-Labeled [alpha]-Melanocyte-Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection

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The Journal of Nuclear Medicine
Article date:
May 1, 2008
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Peptide-targeted α-therapy with 7.4 MBq of ^sup 212^Pb-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-ReO-[Cys^sup 3,4,10^, D-Phe^sup 7^,Arg^sup 11^]α-MSH^sub 3-13^ (^sup 212^Pb-DOTA-Re(Arg^sup 11^)CCMSH) cured 45% of B16/F1 murine melanoma-bearing C57 mice in a 120-d study, highlighting its melanoma treatment potential. However, there is a need to develop an imaging surrogate for patient-specific dosimetry and to monitor the tumor response to ^sup 212^Pb-DOTA-Re(Arg^sup 11^)CCMSH therapy. The purpose of this study was to evaluate the potential of ^sup 203^Pb-DOTA-Re(Arg^sup 11^)CCMSH as a matched-pair SPECT agent for ^sup 212^Pb-DOTA-Re(Arg^sup 11^) CCMSH. Methods: ...

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