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Tissue engineering approaches for the construction of a completely autologous tendon substitute

Introduction

Tendons are soft connective tissues, which connect muscle to bone and form a musculo-tendinous unit, whose primary function is to transmit tensile loads generated by muscles to move and stabilize joints. The biomechanical properties of tendons can be attributed to the highly defined organization of their extracellular matrix (ECM). ECM of tendons is primarily composed of collagen I, and is organized in a hierarchy of bundles that are aligned in a parallel manner in a proteoglycan matrix. Tendon injuries produce considerable morbidity, and the disability that they cause may last for several months despite what is considered appropriate management. The basic cell biology of ...

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