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Secondary osteoporosis due to sickle cell anemia: Do sex steroids play a role?

Introduction

The prevalence of osteoporosis in premenopausal Saudi Arabian women is reported to be 10%; and in postmenopausal women, between 30% and 40%, which is higher in comparison to that in other parts of the world [1],[2],[3],[4] In 20% to 30% of postmenopausal women and in more than 50% of men, osteoporosis is due to secondary causes. [5] Bones are sensitive to diseases, which may cause secondary osteoporosis such as hormonal and due to drugs like steroids and chemotherapeutic agents. [6] Recently SCD has been added to the list of diseases which cause secondary osteoporosis. [7],[8],[9],[10]

The importance of testosterone in men with osteoporosis has been challenged now, and reports ...

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