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Longitudinal Clinical Evaluation of a Novel Antibody Cocktail for Detection of High-Grade Squamous Intraepithelial Lesions on Cervical Cytology Specimens
- Article from:
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Archives of Pathology & Laboratory Medicine
- Article date:
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June 1, 2008
- Author:
- Tambouret, Rosemary H; Misdraji, Joseph; Wilbur, David C
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Copyright informationCopyright College of American Pathologists Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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* Context.-Although cervical cancer screening by cytology is successful, the test continues to show relatively poor operating characteristics. Cell cycle markers may enhance detection of high-grade squamous intraepithelial lesions.
Objective.-To determine the clinical usefulness of ProExC, an immunocytochemical assay for cell cycle components, performed on routine cervical cytology samples.
Design.-Cervical cytology samples were collected using the SurePath method. Residual cells remaining after preparation of the Papanicolaou-stained slide were used to make a second slide for ProExC staining using an indirect polymer-based immunoperoxidase method. Only adequately cellular slides were ...