Evidence-Based Pathology and the Pathologic Evaluation of Thymomas: Transcapsular Invasion Is Not a Significant Prognostic Feature

* Context.-Evaluation of transcapsular invasion is currently considered very important in the pathologic examination of thymomas. However, recent studies have questioned the prognostic value of stratifying thymoma patients into stage I and II disease. Evidence-based pathology promotes the use of systematic reviews of literature and metaanalysis of data to synthesize the results of multiple publications.

Objective.-To analyze the data in the literature regarding the prognostic importance of transcapsular invasion in thymoma stage I and II.

Design.-A systematic review of the English literature was carried out for ''thymoma,'' ''stage,'' and ''prognoses.'' Case reports, case series with fewer ...

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