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Clinicopathologic Significance of Nuclear Grooves and Inclusions in Renal Cell Carcinoma: Image Database Construction and Quantitative Scoring
- Article from:
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Archives of Pathology & Laboratory Medicine
- Article date:
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June 1, 2008
- Author:
- Lee, Ju-Han; Han, Eun Mee; Lin, Zhen-Hua; Wu, Zheng-Sheng; Lee, Eung-Seok; Kim, Young-Sik
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Copyright informationCopyright College of American Pathologists Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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* Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized.
Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in RCC.
Design.-The frequencies or scores of nuclear grooves and inclusions were compared with the histologic subtype, nuclear grade, and TNM stage, as well as overall survival of RCC patients. For objective counting of nuclear irregularities, a relational image database was constructed and used for quantitative assessment.
Results.-Nuclear grooves and inclusions were seen in 96% and 65% of 110 RCC cases, respectively. The ...