'Signature' of Chromosome Instability Predicts Cancer Outcomes; Research...

Ascribe Higher Education News Service;  August 20, 2006 ;     611 words ......that a genetic profile indicating chromosomal instability - an increased tendency to develop...Nature Genetics on August 20. Chromosomal instability is one of the key mechanisms that...easy way to measure the level of chromosomal instability in a given tumor sample. The technique...

New Tool Could Help Determine Cancer Treatment

Morning Edition (NPR);  August 21, 2006 ;   STEVE INSKEEP;   621 words ......useful to get a handle on how much chromosomal instability there was in a particular tumor...which we can estimate the level of chromosomal instability in cancer. PALCA: The method takes...of 25 genes that are related to chromosomal instability. The way these genes express ...

Chromosomal instability can predict cancer

The Hindustan Times;  August 21, 2006 ;     198 words ......that a genetic profile indicating chromosomal instability, an increased tendency to develop...12 of the populations studied. "Chromosomal instability is one of the key mechanisms that...easy way to measure the level of chromosomal instability in a given tumor sample," he added...

Wisconsin Inventors Develop Microsatellite Loci Analyzing Method

US Fed News Service, Including US State News;  April 18, 2007 ;     241 words ......developed a method of detection of microsatellite instability and its use in diagnosis of tumors...disclosed for use in the analysis of microsatellite instability in genomic deoxyribonucleic acid...disclosed which can be used to detect microsatellite instability DNA present in ...

US scientists develop new disease assessment test

Yorkshire Post;  August 21, 2006 ;     213 words ......of patients. The technique, which looks for signs of chromosomal instability, is expected to help doctors gauge different grades...genes whose abnormal activity most strongly predicted chromosomal instability. The genes provided a "profile" that significantly predicted...

Wisconsin Inventors Develop Cancer Diagnosis Utilizing Microsatellite...

US Fed News Service, Including US State News;  June 23, 2008 ;     231 words ......disclosed for use in the analysis of microsatellite instability in genomic deoxyribonucleic acid...disclosed which can be used to detect microsatellite instability DNA present in biological materials...diagnose diseases associated with microsatellite instability, such as certain ...

Screening for Lynch syndrome.(Brief Article)

Internal Medicine News;  June 15, 2005 ;   Evans, Jeff;   210 words ......abnormalities of microsatellite instability were detected...high-frequency microsatellite instability on genotyping...low-frequency microsatellite instability on genotyping...

Identification of numerical chromosomal changes detected by interphase...

Archives of Pathology & Laboratory Medicine;  February 1, 2002 ;   Al-Maghrabi, Jaudah; Vorobyova, Lada; Toi, A; Chapman, William; Et al;   787 words ......Objective.-To determine whether chromosomal instability in these precursor lesions could...from those who do not. The term chromosomal instability refers to a high frequency of...human cancer biology.3,4 Recently chromosomal instability has been described in many human...

Performance of the Revised Bethesda Guidelines for Identification of...

Archives of Pathology & Laboratory Medicine;  November 1, 2005 ;   Gologan, Adrian; Krasinskas, Alyssa; Hunt, Jennifer; Thull, Darcy L; Et al;   787 words ...Context.-Criteria for microsatellite instability (MSI) testing to...histopathologic criteria. Microsatellite instability testing with the...classified into microsatellite instability high (MSI-H), low...

HYPERPLASIA AND CARCINOMA OF THE ENDOMETRIUM

Gynecological Endocrinology;  February 1, 2004 ;   Prat, J;   216 words ......molecular features of the 2 types.The instauration of microsatellite instability in endometrial carcinogenesis seems to occur late...Moreover, the endometrioid adenocarcinomas that exhibit microsatellite instability show a stepwise progressive accumulation of secondary...

The role of microsatellite instability to predict clinical benefit from...

Turkish Journal of Cancer;  April 1, 2008 ;   Artaç, Mehmet; Pehlivan, Sacide; Akcan, Songül; Pehlivan, Mustafa; Gelen, Tekinalp; Aksoy, Nazif; Özdogan, Mustafa; Savas, Burhan; Samur, Mustafa; Bozcuk, Hakan;   787 words ......assess the relationship between microsatellite instability (MSI) and the clinical outcome...56] KEY WORDS: Colon cancer, microsatellite instability, irinotecan, PCR INTRODUCTION...replication and transcription. Microsatellite instability (MSI) is characterized by the...

Reduction of stability of Arabidopsis genomic and transgenic DNA-repeat...

Plant Physiology;  September 1, 2003 ;   Leonard, Jeffrey M; Bollmann, Stephanie R; Hays, John B;   787 words ......dinucleotide-repeat sequences (microsatellite instability) at nine loci in 16 or more progeny...AtMSH2-RNAi plants showed similar microsatellite instability. In wild-type progeny, only one...alleles tested. This endogenous microsatellite instability, shown for the first time in...

Ninety-Six Haploid Yeast Strains With Individual Disruptions of Open...

Genetics;  November 1, 2007 ;   Lehner, Kevin R; Stone, Megan M; Farber, Rosann A; Petes, Thomas D;   787 words ......effect of chromosome context on microsatellite instability. In a previous study (Hawk et...a measurement of the rate of microsatellite instability (Hawk et al. 2005). Rates are...chromosome XV that had elevated microsatellite instability, we constructed 18 derivatives...

MOLECULAR BIOMARKERS FOR CANCER DETECTION IN BLOOD AND BODILY FLUIDS

Critical Reviews in Clinical Laboratory Sciences;  September 1, 2006 ;   Feng, Qinghua; Yu, Mujun; Kiviat, Nancy B;   787 words ......diagnostic marker, prognostic marker, microsatellite instability; genomics; proteomics; circulating...artificial chromosome; BAT-26, microsatellite instability marker, a 26-repeat adenine tract...matrix metallopeptidase 1; MSI, microsatellite instability; MSP, methylation-specific ...

Missing enzyme incites cancer debate.(telomerase)

Science News;  October 11, 1997 ;   Travis, John;   568 words ......the telomeres shortened, more and more cells exhibited chromosomal instability, says DePinho. Some cells had extra or missing chromosomes...without telomerase. Either cancer cells can tolerate the chromosomal instability brought on by a lack of telomerase, or they have an...