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Metallo-[beta]-lactamases of Pseudomonas aeruginosa - a novel mechanism resistance to [beta]-lactam antibiotics

Abstract: Since about twenty years, following the introduction into therapeutic of news β-lactam antibiotics (broad-spectrum cephalosporins, monobactams and carbapenems), a very significant number of new β-lactamases appeared. These enzymes confer to the bacteria which put them, the means of resisting new molecules. The genetic events involved in this evolution are of two types: evolution of old enzymes by mutation and especially appearance of new genes coming for some, from bacteria of the environment. Numerous mechanisms of enzymatic resistance to the carbapenems have been described in Pseudomonas aeruginosa. The important mechanism of inactivation carbapenems is production ...

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