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Naive helper T cells from BCG-vaccinated volunteers produce IFN-[gamma] and IL-5 to mycobacterial antigen-pulsed dendritic cells

Abstract: Mycobacterium bovis bacillus Calmette-Guerin (BCG) is a live vaccine that has been used in routine vaccination against tuberculosis for nearly 80 years. However, its efficacy is controversial. The failure of BCG vaccination may be at least partially explained by the induction of poor or inappropriate host responses. Dendritic cells (DCs) are likely to play a key role in the induction of immune response to mycobacteria by polarizing the reactivity of T lymphocytes toward a Th1 profile, contributing to the generation of protective cellular immunity against mycobacteria. In this study we aimed to investigate the production of Th1 and Th2 cytokines by naive CD4^sup +^ T cells to ...

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