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Article: Hypoxia and Alzheimer disease/One of the authors responds
- Article from:
- Canadian Medical Association. Journal
- Article date:
- June 17, 2008
- Author:
CopyrightCopyright Canadian Medical Association Jun 17, 2008. Provided by ProQuest LLC. (Hide copyright information)
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Christopher Patterson and colleagues reviewed the modifiable risk factors for Alzheimer disease but did not mention that hypoxia may stimulate the development of this illness.1 Cigarette smoking, severe head injury with loss of consciousness and systolic hypertension in older people are risk factors that may cause hypoxia directly or induce it via neuronal ischemia; the disruption of neurovascular coupling has been implicated in hypertension,2 ischemic stroke and Alzheimer disease. We are interested in the authors' views on this issue as many patients with Alzheimer disease also have vascular infarctions3 and these patients deteriorate faster.4
Prolonged or chronic hypoxia has been shown to ...