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Article: Aspirin Responsiveness in Healthy Volunteers Measured with Multiple Assay Platforms
- Article from:
- Clinical Chemistry
- Article date:
- June 1, 2008
- Author:
CopyrightCopyright American Association for Clinical Chemistry Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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BACKGROUND: We evaluated the sensitivity, precision, and concordance of 4 assays designed to detect aspirin responsiveness or resistance.
METHODS: Twenty-nine healthy laboratory volunteers took 80 mg aspirin for 7 days, and a subset of volunteers took 325 mg aspirin for an additional 7 days. We measured platelet function by light transmission aggregometry with arachidonic acid, PFA-100, and VerifyNow. PFA-100 and VerifyNow assays were performed in duplicate to assess method imprecision. Some volunteers had samples taken within 2-4 h of the final dose of aspirin and again within 20-24 h of the final dose. We measured urinary 11-dehydro-thromboxane B^sub 2^ at baseline and after 80 or 325 mg ...