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Antibody Drug Conjugates: A Marriage of Biologics and Small Molecules
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Pharmaceutical Technology
- Article date:
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June 1, 2008
- Author:
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Copyright informationCopyright Advanstar Communications, Inc. Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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Antibody drug conjugates offer a niche opportunity in drug development and contract manufacturing.
Targeted therapies such as monocolonal antibodies are an important part of anticancer drug development. Humanized antibodies may be used either alone in unlabeled or naked form or conjugated with radioactive isotopes, chemotherapeutics, or toxins to create highly targeted agents. Antibody drug conjugates (ADCs), or monoclonal antibodies linked to a cytotoxic small molecule, provide a niche opportunity for biopharmaceutical companies and contract manufacturers.
Monclonal antibodies target cancer
Six engineered monoclonal antibodies ["Rituxan" (rituximab), "Herceptin" (trastuzumab), "Campath" ...
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