Abstract The p38α mitogen-activated protein kinase (MAPK) is essential in controlling the production of many proinflammtory cytokines, and its specific inhibitor can effectively block their production for treating human diseases. To effectively identify highly specific p38α inhibitors in vivo, we developed an ex vivo mouse blood cell-based assay by flow cytometry to measure the intracellular p38α kinase activation. We first attempted to identify the individual blood cell population in which the p38α kinase pathway is highly expressed and activated. Based on CD11b, combined with Ly-6G cell surface expression, we identified two distinct subsets of non-neutrophilic myeloid ...

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