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Article: Isolation and characterization of mesenchymal stem cells derived from bone marrow of patients with Parkinson's disease
- Article from:
- In Vitro Cellular & Developmental Biology
- Article date:
- May 1, 2008
- Author:
CopyrightCopyright Society for In Vitro Biology May/Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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Abstract Mesenchymal stem cells (MSCs) are capable of self-renewing and differentiating into multiple tissues; they are expected to become a source of cells for regenerative therapy. Compared to allogeneic MSCs, autologous MSCs from patients needing cell-based therapy may be an ideal alternative stem cell source. However, characterizations of MSCs from a disease state remains extremely limited. Therefore, we have isolated and characterized MSCs from Parkinson's disease (PD) patients and compared them with MSCs derived from normal adult bone marrow. Our results show that PD-derived MSCs are similar to normal MSCs in phenotype, morphology, and multidifferentiation capacity. Moreover, ...