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Suspected cardiac toxicity to intravenous immunoglobulin used for treatment of scleromyxedema

Introduction

Lichen myxedematosus is a rare skin disease characterized by the deposition of acid glycosaminoglycans in the dermis, leading to the formation of numerous lichenoid papules, causing thickening and hardening of the skin. The generalized form is called scleromyxedema, in which diffuse thickening of the skin underlies the papules. The tumorous variant is very rare. Scleromyxedema may be associated with systemic involvement and can be fatal. The various therapeutic options available have only partial efficacy and are often associated with toxic side effects. We report a case of scleromyxedema treated with intravenous immunoglobulin (IVIg), with almost complete clearing of the skin ...

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