Sir,

There is an increasing awareness of the immune reconstitution inflammatory syndrome (IRIS) in patients initiating antiretroviral therapy. It is likely that there will be more reports of this phenomenon in patients co-infected with HIV and leprosy, especially from India, where there is a high prevalence of both the diseases and antiretroviral therapy is being made available for free by national organizations.

The article by Kharkar et al. [1] raises a number of interesting considerations:

Both cases presented in the article clearly appear to satisfy the clinical and pathologic criteria for the diagnosis of IRIS. However, early definitions of IRIS by French et al., [2] and subsequent ...

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