|
|
Article: Luteal phase physiology and its relevance for steroids and human chorionic gonadotropin treatment
- Article from:
- Gynecological Endocrinology
- Article date:
- May 1, 2008
- Author:
CopyrightCopyright Taylor & Francis Ltd. May 2008. Provided by ProQuest LLC. (Hide copyright information)
|
The human corpus luteum, a temporary endocrine gland derived from the ovulated follicle, is a major source of steroid hormones, producing up to 40 mg of progesterone per day. Unique to the corpus luteum of many primates, including the human, is the secretion of significant amounts of androgens and estradiol, in addition to progesterone. The pattern of progesterone production throughout the luteal phase determines menstrual cyclicity and endometrial receptivity for successful implantation, and is essential for maintenance of early pregnancy. Thus, the underlying endocrine, autocrine/paracrine and molecular mechanisms controlling progesterone production at the time of follicular cell ...