Article: Induction of nitric oxide synthase in rat intestine by interleukin-1alpha may explain diarrhea associated with zinc deficiency

Induction of Nitric Oxide Synthase in Rat Intestine by Interleukin-la May Explain Diarrhea Associated with Zinc Deficiency1

Li Cui, Yoji Takagi, Masafumi Wasa, Yasuhiko liboshi, Jesmine Khan, Riichiro Nezu* and Akira Okada2

Department of Pediatric Surgery and *First Department of Surgery, Osaka University Medical School, Osaka 565, Japan

ABSTRACT Synthesis of inducible nitric oxide synthase (iNOS) in the intestine may result in local tissue damage. We investigated whether a challenge with interleukin-la could give rise to intestinal iNOS expression and diarrhea in rats of differing zinc status. Weaning male rats were fed a zinc-deficient (ZD) diet (2 mg zinc/kg) for 4 wk to induce zinc ...

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