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Article: Induction of nitric oxide synthase in rat intestine by interleukin-1alpha may explain diarrhea associated with zinc deficiency
- Article from:
- The Journal of Nutrition
- Article date:
- September 1, 1997
- Author:
CopyrightCopyright American Institute of Nutrition Sep 1997. Provided by ProQuest LLC. (Hide copyright information)
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Induction of Nitric Oxide Synthase in Rat Intestine by Interleukin-la May Explain Diarrhea Associated with Zinc Deficiency1
Li Cui, Yoji Takagi, Masafumi Wasa, Yasuhiko liboshi, Jesmine Khan, Riichiro Nezu* and Akira Okada2
Department of Pediatric Surgery and *First Department of Surgery, Osaka University Medical School, Osaka 565, Japan
ABSTRACT Synthesis of inducible nitric oxide synthase (iNOS) in the intestine may result in local tissue damage. We investigated whether a challenge with interleukin-la could give rise to intestinal iNOS expression and diarrhea in rats of differing zinc status. Weaning male rats were fed a zinc-deficient (ZD) diet (2 mg zinc/kg) for 4 wk to induce zinc ...