Magazine article from our research archive:

Modeling of Biopharmaceutical Processes. Part 1: Microbial and Mammalian Unit Operations

ABSTRACT

The scale-up of processes from bench to commercial scale is challenging because of uncertainties about the physiochemical environment experienced by the cells at large scale. Process modeling tools can be useful in facilitating the scale-up and technology transfer of microbial and mammalian processes by ensuring that the process requirements can be met by the facility capabilities.

Economies of scale and significant improvements made in the understanding of bioprocesses, design of equipment, and construction of facilities, have driven commercial production of biotech molecules to larger scales in the last decade. Microbial and mammalian commercial processes are routinely performed ...

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