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Hairy cell leukemia: Clinical, pathological and ultrastructural findings in Asian-Indians

Introduction

Hairy cell leukemia (HCL) is an indolent, chronic B-cell lymphoproliferative disorder comprising approximately 2 to 3% of all adult leukemias. [1] It occurs more frequently in men (Ratio 4:1) and mean age at diagnosis is approximately 52 years. It is primarily a disease of Caucasians. [2] This series of patients aims at providing an evaluation of clinical presentation, with special emphasis on electron microscopic findings on cladribine therapy.

Materials and Methods

All HCL cases diagnosed in the Hematology department from December 2001 to January 2004 were evaluated. A histological diagnosis of HCL was done with tartarate-resistant acid phosphatase (TRAP)-positive hairy cells ...

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