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Bone marrow morphological changes in patients of chronic myeloid leukemia treated with imatinib mesylate

Introduction

Chronic myeloid leukemia (CML) is a clonal stem cell disorder associated with the reciprocal translocation between chromosomes 9 and 22 resulting in formation of the bcr-abl chimeric protein with tyrosine (abl) kinase activity. [1] The enhanced tyrosine kinase activity has been associated with expansion of the pluripotent stem cells, defective adhesion and decreased apoptosis of the hematopoietic cells. [1]

The effects of abl kinase activity have been found to be successfully reversed by a novel molecule STI571 or Imatinib Mesylate which specifically binds to the ATP binding site of the bcr-abl kinases and inhibits them. [2] Imatinib mesylate has shown promising results in ...

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