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Immunoprofile of Hodgkin's lymphoma in India

Introduction

Hodgkin's lymphoma (HL), first described by Thomas Hodgkin in 1832 is one of the most enigmatic diseases known. In recent years, immunophenotyping has contributed significantly to our understanding the nature and biology of the diagnostic Reed Sternberg (RS) cell.

It had long been recognized that HL was not a single disease. Today HL has been classified on the basis of immunophenotype of the RS cell into classical HL (cHL) and nodular lymphocyte predominance HL (NLPHL). Moreover, the immunoprofiles of the RS cells and the background lymphocytes have recently been shown to impact the behavior and response to treatment of HL.

HL is not an uncommon lymphoid tumor in India. [1],[2] ...

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