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Observations on the expression of bcg-1 gene in breast tumor and adjacent tissue

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Various clinico-pathological characteristics are evaluated for the management of breast cancer and the predictive value of these variables in determining benefit from endocrine therapy could be further refined by gene expression signatures. [1] Recently it has been shown that bcg-1 gene that is localized on chromosome X, is expressed in breast cancer specimens and not in cell lines and normal mammary epithelium. [2] This gene shows homology with necdin, an inhibitor of cell growth and apoptosis and MAGE (melanoma-associated antigen) genes that play important role in the immune surveillance of certain tumor types. [3] We analyzed tumor samples and normal adjacent tissues obtained ...

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