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A trial design that generates only ''positive'' results
- Article from:
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Journal of Postgraduate Medicine
- Article date:
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July 1, 2008
- Author:
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;
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Copyright informationCopyright Medknow Publications Jul-Sep 2008. Provided by ProQuest LLC. (Hide copyright information)
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Randomized clinical trials (RCTs) are designed to minimize bias in comparative tests of therapeutic effectiveness. However, they are not always free of bias. In recent years, we have seen a plethora of RCTs adopting a design where patients are randomized to receive either usual care (the control group) or usual care plus the experimental treatment. Schematically this design could be depicted as 'A + B versus B'. At first glance, such comparisons may seem reasonable. However, on closer inspection, doubts emerge regarding whether such RCTs are fair scientific tests of the experimental intervention. These doubts originate from the theoretical view that 'A plus B' will invariably amount to more ...
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