Heparin: an important drug enters its seventh decade.

Chemistry and Industry;  January 21, 1991 ;     700+ words ...Heparin: An Important Drug Enters Its Seventh Decade Heparin is the drug most widely used to prevent blood from clotting...Approximately 33 metric tons, representing 500 million doses, of heparin are used worldwide each year. Its anticoagulant activity...

Caution: Heparin errors can have fatal results

Drug Topics;  April 2, 2007 ;     662 words ......stocked an automated dispensing cabinet with heparin 10,000 units/ml vials in a drawer reserved for heparin 10 units/ml. The nurses retrieving the vials...in strength and used the 10,000 units/ ml heparin for umbilical line flushes of six premature...

Heparin: Consider monitoring AT III with long-term therapy

DVM;  May 1, 2003 ;     700+ words ...Q Please provide a brief review on the clinical usefulness of heparin products in dogs and cats. A Heparin has antithrombotic and anticoagulatory activty. Fractionating heparin and using the low molecular weight forms appear to have advantages...

FDA investigates reactions to bolus heparin agent.(News)

Internal Medicine News;  March 1, 2008 ;     604 words ......reactions in patients receiving bolus injections of heparin made by Baxter Healthcare Corp. prompted the company...temporarily stop manufacturing multiple-dose vials of heparin, the Food and Drug Administration announced. Most...reactions were in patients who received a bolus dose of heparin from ...

AN ANESTHESIA PROVIDER'S PERSPECTIVE OF HEPARIN-INDUCED THROMBOCYTOPENIA

AANA Journal;  April 1, 2005 ;     700+ words ...Heparin-induced thrombocytopenia (HIT) is a pathology manifested...the general population. Treatment modalities vary only if heparin will be used during the case. The initial indicator of...Clinical suspicion of HIT remains key to early cessation of heparin (all routes) and initiation of alternative ...

Contaminant Found in Heparin; FDA Probes How Compound Got Into Blood-...

The Washington Post;  March 6, 2008 ;     700+ words ......contaminant" in many samples of Chinese-supplied heparin that may be the cause of hundreds of severe...contaminant, a large molecule similar to heparin, was the result of faulty manufacturing...reduce costs. "We don't know how this heparin-like compound got into the heparin, but...

Heparin-Induced Skin Necrosis: Nurses Beware.

Dermatology Nursing;  December 1, 1998 ;     700+ words ...Heparin, a short-term anticoagulant that is derived from either...been used clinically since 1935 (Celoria et al., 1988). Heparin acts by combining with antithrombin III, a substance in...it has changed the first antithrombin III molecule, the heparin molecule then frees itself and enters another ...

The force-driven conformations of heparin studied with single molecule...

Biophysical Journal;  October 1, 2003 ;     700+ words ......molecule force spectroscopy we examine the response of heparin chains to mechanical stretching. We find that at forces below 200 pN heparin behaves as a simple entropic spring. At ~200 pN heparin displays a large enthalpic elasticity, which is evident...

Heparin scare raises perils of outsourcing

Post-Tribune (IN);  April 13, 2008 ;     700+ words ......processing chemicals from pig guts into heparin -- a blood thinner -- has been linked...processes chemicals from pig guts into heparin, a commonly used blood thinner linked...States and Germany. The problems with heparin from the factory and others like it...

Recent experiences with hexadimethrine for neutralizing heparin after...

Anaesthesia and Intensive Care;  June 1, 1999 ;     700+ words ......Hexadimethrine bromide was used for the neutralization of heparin during cardiac surgery in the late 19S0s. For some...patients. Other drugs for reversing the action of heparin such as heparinase or platelet factor IV are not yet widely available...

Neuraxial anesthesia and analgesia in the presence of standard heparin

Regional Anesthesia and Pain Medicine;  November 1, 1998 ;     700+ words ...Therapeutic anticoagulation dosages of standard heparin are commonly used during the perioperative...cardiac surgery patients (1). Low-dose heparin also is frequently used for prophylaxis...procedures in the presence of standard heparin may be associated with an increased risk...

Heparin-Induced Thrombocytopenia in Hemodialysis Patients.

Nephrology Nursing Journal;  April 1, 2000 ;     700+ words ......our physician said she had a history of heparin-induced thrombocytopenia (HIT). Exactly...underdiagnosed complication associated with heparin administration. Often it goes undetected...decrease in platelet count shortly after heparin administration. Usually the platelet count...

DETERMINATION OF INTACT HEPARIN BY CAPILLARY ELECTROPHORESIS WITH...

Collection of Czechoslovak Chemical Communications;  February 1, 2008 ;     700+ words ...Intact heparin was characterized and determined in model...detection. The CE separation of polydisperse heparin took place in open silica capillaries...glycol) or dextran. The best separation of heparin from excess inorganic ions present in...

FDA URGES TEST OF HEPARIN FOR CONTAMINANTS OFFICIALS FEAR DEATHS AND...

Wisconsin State Journal (Madison, WI);  March 7, 2008 ;     462 words ......a different brand of the blood thinner heparin than was linked to 19 American deaths...Administration urged all U.S. suppliers of heparin to start using some special high-tech...linked to Baxter International's U.S.-sold heparin injections. Baxter buys its heparin from...

Heparin-induced thrombocytopenia: Pathogenesis, management, and prevention

Formulary;  January 1, 2001 ;     700+ words ...ABSTRACT Heparin-induced thrombocytopenia (HIT) is a relatively...common but underrecognized complication of heparin administration. It can lead to devastating...While immediate discontinuation of all heparin exposure is the essential foundation of...