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Symptomatic hypocalcemia following intravenous administration of zoledronic acid in a breast cancer patient

Bisphosphonates are increasingly being incorporated in the management of patients with breast cancer. [1] With wider adoption of bisphosphonates, the incidence of some rare complications like hypocalcaemia might go up, particularly in vitamin D deficient populations. Here we would like to share our experience of managing a patient, who developed symptomatic hypocalcaemia after intravenous (IV) infusion of zoledronic acid, to highlight the need of anticipating this preventable, and potentially fatal complication.

A 70-year-old lady presented to us with right breast cancer with multiple skeletal metastases. She was put on chemotherapy along with three-weekly IV infusion of 4 mg zoledronic ...

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