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Kayser-Fleischer ring

Kayser-Fleischer ring (K-F ring), also referred to as Fleischer-Kayser ring or Fleischer-Strumpell ring was first described by the German ophthalmologists Bernhard Kayser (1902) and Bruno Fleischer (1903) independently in a patient who was then diagnosed to have multiple sclerosis. Fleischer in 1912 recognized it as a part of Wilson's disease (WD). [1] Early workers believed the corneal coloration to be due to endogenous deposition of heavy metals like silver and copper. This hypothesis was supported by the findings of large amounts of silver and copper in the viscera by Rumpel. [1] Policard, Bonnet and Bonamour (1936) histospectroscopically demonstrated the presence of copper and the ...

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