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Epistasis and Genetic Regulation of Variation in the Arabidopsis Metabolome

Many factors contribute to genetic and phenotypic variation within an interbreeding population. Phenotypic variation within a species or population is highly complex; it is often polygenic and quantitative and influenced by environmental and genetic factors. In addition to considerations of allelic variation (dominance), it is recognized that both additive and nonadditive (epistatic) interactions between genes and within gene networks may play an important role. Epistasis describes a nonadditive genetic interaction that results from the activity (or mutation) of one gene masking the phenotype or effect caused by the activity of another gene. This can be contrasted with dominance, which ...

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