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Uncommon neurological manifestations of hemolytic anemia: A report of two cases

Sickle cell disease (SCD), the homozygous state for sickle cell gene (SS Hb pattern) is an important risk factor in the development of stroke and most strokes occur in subjects under the age of 15 years. By contrast, sickle cell trait (SCT-AS Hb pattern) is considered to be a benign condition. In spite of a number of case reports, it is not widely appreciated that SCT can cause cerebral infarction. Radhakrishnan et al. , reported two cases of stroke in young with SCT. [1] However, chorea in SCT has not been described in the literature to the best of our knowledge even though a case was reported in HbSC disease. [2]

Hereditary spherocytosis (HS) is a common type of hemolytic anemia and till ...

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