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Effect of Olanzapine and Risperidone on Subjective Well-Being and Craving for Cannabis in Patients With Schizophrenia or Related Disorders: A Double-Blind Randomized Controlled Trial

Objective: To examine whether subjective well-being and craving for cannabis were different in patients with schizophrenia or related disorders treated with either olanzapine or risperidone.

Method: A 6-week, double-blind, randomized trial of olanzapine and risperidone was carried out in 128 young adults with recent onset schizophrenia or related disorders. Primary efficacy measures were the mean baseline-to-endpoint change in total scores on the Subjective Well-Being under Neuroleptics scale, the Obsessive-Compulsive Drug Use Scale, the Drug Desire Questionnaire, and the cannabis use self-report. An analysis of covariance was used to test between-group differences.

Results: Estimated D^sub ...

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