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THE EFFECT OF ADENOSINE A^sub 1^ RECEPTOR ANTAGONISM ON RETURN OF SPONTANEOUS CIRCULATION AND SHORT-TERM SURVIVAL IN PROLONGED VENTRICULAR FIBRILLATION
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Prehospital Emergency Care
- Article date:
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July 1, 2008
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Copyright informationCopyright Taylor & Francis Ltd. Jul-Sep 2008. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Background. Endogenous adenosine (ADO) is cardioprotective during ischemia and its myocardial concentration increases during untreated ventricular fibrillation (VF). We have previously shown that ADO A^sub 1^ receptor (ADOAi R) antagonism hastens the time-dependent decay in VF waveform morphology during the circulatory phase of cardiac arrest. Objective. To determine the effect of ADOA^sub 1^R antagonism on ROSC and short-term survival in prolonged VF. Methods. Thirty-six swine were assigned by block randomization to one of three groups: a group that received only vehicle (CONTROL), an ADOA^sub 1^R antagonist pretreatment group (PRE), and a group that was given ADOA^sub 1^R ...
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