Copper Deficiency Decreases Complex IV but Not Complex I, II, III, or V in...

The Journal of Nutrition;  January 1, 2007 ;     700+ words ......ultrastructural changes and reduction of CCO activity suggest that mitochondrial energy production...electron transport chain. The reduction of CCO activity in hearts of Cu-deficient animals (5...also contribute to the loss of cardiac CCO activity. It has been reported that Cu ...

Application of compartmental modeling to determination of trace element...

The Journal of Nutrition;  September 1, 1996 ;     700+ words ......model. The simulation indicated that a reduction in dietary Cu intake could result in (1) loss of Cu from storage compartments...Whether the body conserves Cu by adapting metabolically to low Cu intake or, alternatively, undergoes significant Cu loss because of...

Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats...

The Journal of Nutrition;  June 1, 2004 ;     700+ words ......CCO is not an antioxidant enzyme per se, the reduction in CCO activity may also contribute to oxidative stress during copper deficiency...mitochondrial H^sub 2^O^sub 2^ production (20). Thus, reduction in CCO activity caused by copper deficiency may result in overproduction...

SECOND IN A SERIES: NUTRITION AND BRAIN FUNCTION

US Fed News Service, Including US State News;  September 1, 2007 ;     700+ words ......energy in the body. "The electron transport chain is involved in mitochondrial energy production," says Johnson. Impaired CCO activity--associated with copper deficiency--can damage rat brain mitochondria and their critical metabolic pathways. An early GFHNRC...

Increased rat brain cytochrome c correlates with degree of perinatal...

The Journal of Nutrition;  November 1, 2003 ;     700+ words ......chain essential for the maintenance of cellular energy metabolism through oxidative phophorylation. In copper-deficient rats, CCO activity can be reduced by as much as 80% (9). Analysis of brain tissue from male brindled mutant mice (Mo^sup br/y^), a genetic model...

ATP7A Transgenic and Nontransgenic Mice Are Resistant to High Copper...

The Journal of Nutrition;  April 1, 2008 ;     700+ words ......investigate the effect of overexpression of ATP7A when dietary Cu intake was markedly increased, normal and transgenic mice were exposed...particular are extremely sensitive to even a minor increase in Cu intake, because this species has very inefficient biliary Cu excretion...

Inadequate copper intake reduces serum insulin-like growth factor-I and...

The Journal of Nutrition;  February 1, 2003 ;     700+ words ......determinant of most of the variables related to bone quality. Low Cu intake reduced serum IGF-I and femur breaking force and ultimate stress...increased bone IGF-I concentration (by 62%; P < 0.0001). Low Cu intake also increased femur nitrogen, hydroxyproline, hexosamine and...

Placental copper transport in rats: Effects of elevated dietary zinc on...

The Journal of Nutrition;  June 1, 1998 ;     700+ words ......Reinstein et al. 1984). We designed this study to determine the extent to which a high Zn diet, as defined in the text, with normal Cu intake, fed to pregnant rats would affect Cu and Fe transport from dam to placenta and placenta to fetus, as well as the mineral status...

Pinto Beans Are a Source of Highly Bioavailable Copper in Rats1

The Journal of Nutrition;  December 1, 2006 ;     700+ words ......That Cu specifically could contribute to the health effects of beans is evidenced by a variety of findings. On the one hand, Cu intake is thought to be low in a considerable proportion of the population (11-13), suggesting room for improvement in Cu status...

Administration of the oral antibiotic frenolicin-B selectively alters...

The Journal of Nutrition;  December 1, 2001 ;     700+ words ......those in the ad libitum controls, indicating that the FB-mediated decrease in plasma Cu was not a consequence of a reduced Cu intake. The decrease in plasma copper concentrations by 70% or ~90 (mu)g/dL (14 (mu)mol/L) after 4 wk of FB ingestion is comparable...